The Prostate Health Index In Predicting Initial Prostate

3 hours ago PHI was the best predictor of prostate biopsy results, especially in patients with a tPSA of 10.1–20 ng ml−1. Compared with other markers, at a sensitivity of 91%, PHI was the most useful for determining which men did not need to undergo biopsy, …

Author: Guo Peng Yu, Rong Na, Ding Wei Ye, Jun Qi, Fang Liu, Fang Liu, Hai Tao Chen, Yi Shuo Wu, Gui Ming Zh...
Publish Year: 2016

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Just Now Abstract Purpose To investigate the role of the Prostate Health Index (phi) in prostate cancer (PCa) detection in patients with a prostate-specific antigen (PSA) level of 4–10 ng/mL receiving their first prostatic biopsy in an Asian population. Methods This was a retrospective study of archived serum samples from patients enlisted in our tissue bank.

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2 hours ago The Prostate Health Index in predicting initial prostate biopsy outcomes in Asian men with prostate-specific antigen levels of 4-10 ng/mL. Ng CF1, Chiu PK, Lam NY, Lam HC, Lee KW, Hou SS Author information Affiliations 1 author 1. Division of Urology, Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China,

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1 hours ago Background: Men with elevated prostate-specific antigen (PSA) and initial negative prostate biopsy may have risk of prostate cancer (PCa) in the future. The role of Prostate Health Index (phi) in determining future PCa risk has not been studied before. This study aims to investigate the role of initial phi and phi density in predicting future PCa risk in men with initial negative …

Author: Alex Qinyang Liu, Sebastiaan Remmers, Sui-Yan Lau, Siu-Ying Yip, Chi-Ho Leung, Christy Wing-Hin Mak,...
Publish Year: 2021

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7 hours ago To investigate the role of the Prostate Health Index (phi) in prostate cancer (PCa) detection in patients with a prostate-specific antigen (PSA) level of 4-10 ng/mL receiving their first prostatic

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3 hours ago The Prostate Health Index (PHI) is a new formula that combines all three forms (total PSA, free PSA and p2PSA) into a single score that can be used to aid in clinical decision-making [Catalona et al.2011]. PHI is calculated using …

Author: Stacy Loeb, William J. Catalona
Publish Year: 2014

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3 hours ago The prostate health index (PHI), developed by Beckman Coulter, Inc., is a mathematical formula combining three biomarkers as follows: (p2PSA/fPSA) × √tPSA. Numerous studies have shown that the %p2PSA and PHI are the most accurate predictors of PCa at …

Author: Yung-Ting Cheng, Chao-Yuan Huang, Chung-Hsin Chen, Shih-Ting Chiu, Jian-Hua Hong, Yeong-Shiau Pu, Sh...
Publish Year: 2020

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1 hours ago Background: It remains unclear whether the Prostate Health Index (PHI) or the urinary Prostate-Cancer Antigen 3 (PCA-3) score is more accurate at screening for prostate cancer (PCa). The aim of this study was to prospectively compare the accuracy of PHI and PCA-3 scores to predict overall and significant PCa in men undergoing an initial prostate biopsy.

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Just Now The PHI or Prostate Health Index test is a blood test that is used to predict the risk of having prostate cancer in men. The PHI test is used instead of the traditional PSA test. The Prostate Health Index test is actually derived from the PSA test. The PHI test is a combination of the free PSA, total PSA, and the [-2]proPSA isoform of free PSA.

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1 hours ago Background: Few prospective studies have focused on the performance of the Prostate Health Index (PHI) in Asian populations. Therefore, we aimed to evaluate the performance of the PHI in predicting prostate cancer (PCa) compared with standard prostate-specific antigen (PSA) tests.

Author: Yu-Hua Fan, Yu-Hua Fan, Po-Hsun Pan, Tzu-Ping Lin, Tzu-Ping Lin, Tzu-Hao Huang, Tzu-Hao Huang, Tzu-C...
Publish Year: 2019

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2 hours ago The prostate health index in predicting initial prostate biopsy outcomes in Asian men with prostate-specific antigen levels of 4-10 ng/mL. Int Urol Nephrol 2014; 46: 711-7. 18. Loeb S, Catalona WJ. The prostate health index: a new test for the detection of prostate cancer.

Author: Guo Peng Yu, Rong Na, Ding Wei Ye, Jun Qi, Fang Liu, Fang Liu, Hai Tao Chen, Yi Shuo Wu, Gui Ming Zh...
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Publish Year: 2016
Printed: 108

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Just Now The Prostate Health Index: Filling the Diagnostic Gap Results of the multi-center pivotal clinical trial showed that Beckman Coulter phivalues significantly enhanced the clinical specificity for prostate cancer detection in men with PSA in the the 4 to 10 ng/mL PSA range.3

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3 hours ago The Beckman Coulter Prostate Health Index combines total, free and [-2]proPSA into a single score. Large prospective multicenter studies in the U.S. and Europe have demonstrated that phi improves prostate cancer detection,7leading to its recent FDA approval as an aid to early prostate cancer detection for men with a PSA of 4 to 10 ng/ml.

Author: Stacy Loeb, Martin G. Sanda, Dennis L. Broyles, Sanghyuk S. Shin, Chris H. Bangma, John T. Wei, Alan...
Publish Year: 2015

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1 hours ago PHI was more accurate than PCA3 for predicting prostate cancer in the initial setting (AUC 0.69 vs 0.57) and in the repeat setting (AUC 0.72 vs 0.63), although no statistically significant difference was observed.

Author: Vincenzo Scattoni, Massimo Lazzeri, Giovanni Lughezzani, Stefano De Luca, Roberto Passera, Enrico Bo...
Publish Year: 2013

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7 hours ago The Prostate Health Index (phi) is a new test combining total, free and [-2]proPSA into a single score. It was recently approved by the FDA and is now commercially available in the U.S., Europe and Australia.

Author: Stacy Loeb, Martin G. Sanda, Dennis L. Broyles, Sanghyuk S. Shin, Chris H. Bangma, John T. Wei, Alan...
Publish Year: 2015

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7 hours ago In this study, we aimed to validate the Prostate Health Index (PHI) for the detection of prostate cancer (PCa). We prospectively enrolled patients aged 50–75 years with a serum prostate specific antigen (PSA) level of 4–10 ng/mL undergoing transrectal biopsy of the prostate between April 2016 and May 2017.

Author: Po Fan Hsieh, Chao Hsiang Chang, Chi Rei Yang, Chi Ping Huang, Wen Chi Chen, Chin Chung Yeh, Eric Ch...
Publish Year: 2018

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Transcript and References

  • Introduction. ...
  • Disclosure. ...
  • Utilization Message. ...
  • Prostate Cancer (PCa) Statistics: 2017. ...
  • Advances in Prostate Cancer Diagnosis. ...
  • PSA Limitations. ...
  • PSA Isoforms in Serum. ...
  • PSA Isoforms in Prostate Cancer. ...
  • phi Specificity for Men with PSA 4–10 mg/mL. ...

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What is prostate health index?

Prostate Health Index ( phi) is a simple, FDA-approved blood test that helps determine the probability of detecting prostate cancer with a biopsy. This test uses an algorithm to assess total PSA, free PSA, and p2PSA, and is recommended by the National Comprehensive Cancer Network (NCCN) guidelines for early cancer detection prior to biopsy.

What psa level indicates prostate cancer?

When PSA levels are:

  • Below 4: 15% chance of prostate cancer.
  • Between 4 and 10 (the borderline range): 25% chance of prostate cancer.
  • Above 10: More than 50% chance of having prostate cancer.

What is the prostate health index test?

  • About 1 death from prostate cancer would be avoided.
  • 120 men would have a false-positive test result that leads to a biopsy, and some men who get a biopsy would experience at least moderately bothersome symptoms from the biopsy.
  • 100 men would be diagnosed with prostate cancer. ...

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